Caracterización de la reacción nuclear de la terapia de captura neutrónica por Boro (BNCT) por medio de Geant4

PDF

Palabras clave

Captura neutrónica
neutrones epitérmicos
Geant4

Cómo citar

Medina, R., Téllez, D., Munévar, E., & Leyva, J. (2018). Caracterización de la reacción nuclear de la terapia de captura neutrónica por Boro (BNCT) por medio de Geant4. Revista Investigaciones Y Aplicaciones Nucleares, (2), 43-54. https://doi.org/10.32685/2590-7468/invapnuclear.2.2018.5

Resumen

El propósito principal en este trabajo es determinar evento por evento el conteo, la distribución de energía, la distribución de momento y la distribución angular de las partículas producidas en la reacción nuclear principal que tiene lugar en la terapia de captura neutrónica por boro (BNCT) [10B (n, α)7Li]. Además de una breve revisión histórica, se presentan los resultados obtenidos de la simulación computacional con Geant4 de la reacción nuclear que tiene lugar en la BNCT.

https://doi.org/10.32685/2590-7468/invapnuclear.2.2018.5
PDF

Citas

-[1] J. Chadwick, F. R. S., “The Existence of a Neutron”, Proc. R. Soc. Lond. A., vol. 136, n.° 830, jun., 1932, pp. 692-708.

-[2] H. J. Taylor y M. Goldhaber, “Detection of Nuclear Disintegration in a Photographic Emulsion”, Nature, vol. 136, n.° 3409, mar., 1935, p. 341.

-[3] L. Gordon, “Biological Effects and Therapeutic Possibilities of Neutrons”, Am. J. Roentgenol. Radium Ther., vol. 36, 1936, pp. 1-13.

-[4] K. Hanaoka, T. Watabe, S. Naka et al., “FBPA PET in Boron Neutron Capture Therapy for Cancer: Prediction of 10B Concentration in the Tumor and Normal Tissue in a Rat Xenograft Model”, EJNMMI Research, vol. 4, n.° 4, 2014, pp. 1-8.

-[5] N. S. Hosmane, J. A. Maguire, C. Salt, et al., “Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment”, en L. E. Feinendegen, comp., World Scientific, EE. UU.: Treatment United States Departmentof Energy Office of Science, 2012.

-[6] L. Kankaanranta, T. Seppälä, H. Koivunoro et al., “Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial”. Int. J. Radiat. Oncol. Biol. Phys., vol. 82, 2012, pp. 67-75.

-[7] L. Moghaddasi y E. Bezak, “Development of an Integrated Monte Carlo Model for Glioblastoma Multiforme Treated with Boron Neutron Capture Therapy”, Scientific Reports, vol. 7, n.° 1, 2017, p. 7069.

-[8] D. A. Téllez, R. S. Medina, E. Munévar y J. A. Leyva, “Computational Approach to the Interaction of 7Li Coming from Neutron Capture on Biological Cells Via Geant4”, en Lasnpa & Wonp-Nurt 2017, Program and abstracts, 2017, p. 126.

-[9] S. Agostinelli, J. Allison, K. Amako, et al., “Geant4: A Simulation Toolkit, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 506, n.° 3, 2003, pp. 250-303.

-[10] Geant4 Collaboration, Geant4 User’s Guide for Application Developers, version 10.4, 2017.

-[11] L. Moghaddasi y E. Bezak, “Geant4 Beam Model for Boron Neutron Capture Therapy: Investigation of Neutron Dose Components”, Australasian Physical & Engineering Sciences in Medicine, vol. 41, 2018, pp. 129-141.

-[12] P. G. Kruger. “Some Biological Effects of Nuclear Disintegration Products on Neoplastic Tissue”, Proceedings of the National Academy of Sciences, vol. 26, n.° 3, 1940, pp. 181-192.

-[13] W. A. Sauerwein, A. Witting, R. Moss y Y. Nakagawa, Neutron Capture Therapy. Berlín: Springer-Verlag Berlin Heidelberg, 2012.

-[14] W. H. Sweet, “Early History of Development of Boron Neutron Capture Therapy of Tumors”, Neuro-Oncology, vol. 33, n.° 1, may, 1997, pp. 19-26.

-[15] A. H. Soloway, H. Hatanaka y M. A. Davis, “Penetration of Brain and Brain Tumor. vii. Tumor-Binding Sulfhydryl Boron Compounds”. Journal of Medicinal Chemistry, vol. 10, n.° 4, jul, 1967, pp. 714-717.

-[16] O. K. Harling, F. J. Wheeler, J. A. Bernard et al., “Neutron Beam Design: Development, and Performance for Neutron Capture Therapy”, en Basic Life Sciences, vol. 54, Nueva York: Springer US, 1990.

-[17] Y. Mishima, Cancer, Neutron Capture Therapy, Nueva York: Springer US, 1996.

-[18] J. Allison, K. Amako, J. Apostolakis, et al., “Recent Developments in Geant4”. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 835, 2016, pp. 186-225.

-[19] R. Bevilacqua, F. J. Hambsch, M. Vidali et al., “10B (n, α)7Li and 10B (n, α1γ)7 Li Cross Section Data up to 3 MeV Incident Neutron Energy”, EPJ Web of Conferences 146, p. 11010, 2017.

-[20] A. Karaoglu, P. Arce, D. Obradors et al., “Calculation by Gamos/Geant4 Simulation of Cellular Energy Distributions from Alpha and Lithium-7 Particles Created by BNCT”, Appl Radiat Isot, vol. 132, 2018, pp. 206-211.

Número de Visitas

Resumen : 350 vistas.

Descargas

La descarga de datos todavía no está disponible.