Absorbed dose to water standard for 192Ir HDR sources using Fricke Dosimetry
DOI:
https://doi.org/10.32685/2590-7468/invapnuclear.4.2020.565Keywords:
HDR, Fricke dosimetry, absorbed dose
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Abstract
The Fricke solution is a chemical dosimeter that is based on the oxidation of ferrous ions to ferric ions in the solution after interaction with ionizing radiation. It is composed of 96% water (by weight), and its density is thus remarkably similar to that of water. In addition, studies show that the Fricke dosimeter can be used as a primary dosimeter in the determination of the absorbed dose to water for high dose rate (HDR) 192Ir brachytherapy. The Radiological Sciences Laboratory of the University of Rio de Janeiro State (LCR/UERJ) has been investigating the use of the Fricke dosimeter in various applications for more than ten years, particularly in the area of radiotherapy. This review paper presents important improvements in recent years by the LCR/UERJ in the determination of the absorbed dose to water for 192Ir sources. This includes a newly designed irradiation vessel, a new reading device, a description of the need for careful temperature control during irradiation and reading, a more accurate calculation of the correction factors and the results of an intercomparison with the National Calibration Laboratory of Canada. Careful preparation of the Fricke solution is one of the most critical steps in the process. Over the years, the LCR/UERJ has tested different methods of preparing the solution and the final procedure is presented. Regarding the irradiation vessel, a molded double-walled, spherical flask for the Fricke solution was first constructed and used to measure the absorbed dose to water. However, as it was difficult to manipulate the spherical flask, a second design also made with PMMA was molded as a cylinder, with a central tube where the source was centrally positioned. Different methodologies have been reported in the determination of the G-value, a key parameter in Fricke dosimetry, and herein, two different methodologies used by the LCR are reviewed. For the absorbed-dose-to-water determination for 192Ir sources, the overall combined uncertainty associated with the measurements is estimated to be less than 1% for k = 1. Thus, the obtained uncertainties for the determination of the absorbed dose to water using Fricke dosimetry are lower than those obtained using the standard protocols. With respect to clinical practice, this could improve the accuracy in the calculation of the dose delivered to the patients. Overall, the results show that Fricke dosimetry is a reliable system to measure absorbed dose to water as a standard for HDR 192Ir.
References
O. Moussous, S. Khoudri, and M. Benguerba, “Characterization of a Fricke dosimeter at high energy photon and electron beams used in radiotherapy”, Australasian Physical and Engineering Sciences in Medicine, vol. 34, no. 4, pp. 523-528, 2011, https://www.doi.org/10.1007/s13246-011-0093-1.
J. Law and A. T. Redpath, “Measurement of ferric ion concentration in the Fricke dosemeter”, Physics in Medicine & Biology, vol. 16, no. 3, pp. 531-532, 1971, https://www.doi.org/10.1088/0031-9155/16/3/419.
J. Law and A. T. Redpath, “The measurement of low energy x-rays III: Ferrous sulphate G-values”, Physics in Medicine & Biology, vol. 13, no. 3, pp. 371-382, 1968, https://www.doi.org/10.1088/0031-9155/13/3/304.
R. K. Broszkiewicz and Z. Bulhak, “Errors in ferrous sulphate dosimetry”, Physics in Medicine & Biology, vol. 15, no. 3, pp. 549-556, 1970, https://www.doi.org/10.1088/0031-9155/15/3/315.
N. V. Klassen, K. R. Shortt, J. Seuntjens, and C. K. Ross, “Fricke dosimetry: The difference between G(Fe3+) for 60Co γ-rays and high-energy x-rays”, Physics in Medicine & Biology, vol. 44, no. 7, pp. 1609-1624, 1999, https://www.doi.org/10.1088/0031-9155/44/7/303.
“ISO/ASTM 51026: Practice for using the Fricke dosimetry system”, 2015.
E. M. Arango, A. Pickler, A. Mantuano, C. Salata, and C. E. de Almeida, “Feasibility study of the Fricke chemical dosimeter as an independent dosimetric system for the small animal radiation research platform (SARRP)”, Physica Medica: European Journal of Medical Physics, vol. 71, no. March, pp. 168-175, 2020, https://www.doi.org/10.1016/j.ejmp.2020.03.006.
C. Austerlitz et al., “Determination of absorbed dose in water at the reference point D (r 0, θ0) for an 192Ir HDR brachytherapy source using a Fricke system”, Medical Physics, vol. 35, no. 12, pp. 5360-5365, Dec. 2008, https://www.doi.org/10.1118/1.2996178.
A. Olszanski, N. V Klassen, C. K. Ross, and K. R. Shortt, “The IRS Fricke Dosimetry System”, Ottawa, 2002.
C. E. de Almeida et al., “Standard absorbed dose to water for HDR brachytherapy sources with Fricke dosimetry”, IFMBE Proceedings, vol. 25, no. 1, pp. 1055-1056, 2009, https://www.doi.org/10.1007/978-3-642-3474-9-296.
L. Franco, S. Gavazzi, M. Coelho, and C. E. de Almeida, “Determination of the Fricke G Value for HDR 192Ir Sources Using Ionometric Measurements”, in Standards, applications and quality assurance in medical radiation dosimetry (IDOS), International Atomic Energy Agency, 2011.
R. Ochoa, F. Gómez, I. H. Ferreira, F. Gutt, and C. E. de Almeida, “Design of a phantom for the quality control of high dose rate 192Ir source used in brachytherapy”, Radiotherapy and Oncology, vol. 82, no. 2, pp. 222-228, 2007, https://www.doi.org/10.1016/j.radonc.2007.01.005.
C. Salata, M. David, P. Rosado, and C. de Almeida, “SUF-BRA-10: Fricke Dosimetry: Determination of the G-Value for Ir-192 Energy Based On the NRC Methodology”, Medical Physics, vol. 42, no. 6Part26, pp. 3535-3535, 2015, https://www.doi.org/10.1118/1.4925221.
C. Salata et al., “Validating Fricke dosimetry for the measurement of absorbed dose to water for HDR 192Ir brachytherapy: A comparison between primary standards of the LCR, Brazil, and the NRC, Canada”, Physics in Medicine & Biology, vol. 63, no. 8, 2018, https://www.doi.org/10.1088/1361-6560/aab2b8.
C. Salata et al., “SU-F-19A-02: Comparison of Absorbed Dose to Water Standards for HDR Ir-192 Brachytherapy Between the LCR, Brazil and NRC, Canada”, Medical Physics, vol. 41, no. 6Part22, pp. 388-388, 2014, https://www.doi.org/10.1118/1.4889028.
C. B. V. Andrade et al., “Evaluation of radiotherapy and chemotherapy effects in bone matrix using X-ray microfluorescence”, Radiation Physics and Chemistry, vol. 95, 2014, https://www.doi.org/10.1016/j.radphyschem.2013.04.031.
P. H. Rosado et al., “Determination of the absorbed dose to water for medium‐energy x‐ray beams using Fricke dosimetry,” Medical Physics, 2020, https://doi.org/10.1002/mp.14473.
I. El Gamal, C. Cojocaru, E. Mainegra-Hing, and M. McEwen, “The Fricke dosimeter as an absorbed dose to water primary standard for Ir-192 brachytherapy”, Physics in Medicine & Biology, vol. 60, no. 11, pp. 4481-95, 2015, https://www.doi.org/10.1088/0031-9155/60/11/4481.
R. Nath, L. L. Anderson, G. Luxton, K. A. Weaver, J. F. Williamson, and A. S. Meigooni, “Dosimetry of interstitial brachytherapy sources: Recommendations of the AAPM Radiation Therapy Committee Task Group No. 43”, Medical Physics, vol. 22, no. 2, pp. 209-234, 1995, https://www.doi.org/10.1118/1.597458.
M. J. Rivard et al., “Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations”, Medical Physics, vol. 31, no. 3, pp. 633-674, 2004, https://www.doi.org/10.1118/1.1646040.
A. Sarfehnia, K. Stewart, and J. Seuntjens, “An absorbed dose to water standard for HDR 192Ir brachytherapy sources based on water calorimetry: numerical and experimental proof-of-principle”, Medical Physics, vol. 34, no. 12. United States, pp. 4957-4961, Dec. 2007, https://www.doi.org/10.1118/1.2815941.
A. Sarfehnia and J. Seuntjens, “Development of a water calorimetry-based standard for absorbed dose to water in HDR 192Ir brachytherapy”, Medical Physics, vol. 37, no. 4, pp. 1914-1923, 2010, https://www.doi.org/10.1118/1.3366254.
A. Sarfehnia, I. Kawrakow, and J. Seuntjens, “Direct measurement of absorbed dose to water in HDR 192Ir brachytherapy: Water calorimetry, ionization chamber, Gafchromic film, and TG-43”, Medical Physics, vol. 37, no. 4, pp. 1924-1932, 2010, https://www.doi.org/10.1118/1.3352685.
C. E. de Almeida et al., “A Feasibility Study of Fricke Dosimetry as an Absorbed Dose to Water Standard for 192Ir HDR Sources”, PLoS One, vol. 9, no. 12, p. e115155, 2014, https://www.doi.org/10.1371/journal.pone.0115155.
M. McEwen, I. El Gamal, E. Mainegra-Hing, and C. Cojocaru, “Determination of the radiation chemical yield (G) for the Fricke chemical dosimetry system in photon and electron beams”, National Research Council of Canada, 2014. https://www.doi.org/10.4224/23002718.
A. Palm and O. Mattsson, “Influence of sulphuric acid contaminants on Fricke dosimetry”, Physics in Medicine & Biology, vol. 45, no. 9, 2000, https://www.doi.org/10.1088/0031-9155/45/9/403.
M. Mosher, “Organic Chemistry. Sixth edition (Morrison, Robert Thornton; Boyd, Robert Neilson)”, Journal of Chemical Education, vol. 69, no. 11, p. A305, Nov. 1992, https://www.doi.org/10.1021/ed069pa305.2.
A. Pickler et al., “Effects of chemical reactions between Fricke solution and PMMA vessel”, Submiss. Process.
A. O. Fregene, “Calibration of the ferrous sulfate dosimeter by ionometric and calorimetric methods for radiations of a wide range of energy”, Radiation Research, vol. 31, no. 2, pp. 256-72, 1967, [Online]. Available: http://www.ncbi.nlm.nih.gov/pubmed/6025862.
E. Cottens, A. Janssens, G. Eggermont, and R. Jacobs, Absorbed dose calorimetry with a graphite calorimeter,
and G-value determinations for the Fricke dose meter in high-energy electron beams. Viena, International Atomic Energy Agency, 1981.
OECD Nuclear Energy Agency., Penelope: a code system for Monte Carlo simulation of electron and photon transport. Nuclear Energy Agency, 2001.
J. Borg and D. W. Rogers, “Spectra and air-kerma strength for encapsulated 192Ir sources”, Medical Physics, vol. 26, no. 11, pp. 2441-4, Nov. 1999, https://www.doi.org/10.1118/1.598763.
C.-M. Ma and A. E. Nahum, “Dose conversion and wall correction factors for Fricke dosimetry in high-energy photon beams: analytical model and Monte Carlo calculations”, Physics in Medicine & Biology, vol. 38, no. 1, pp. 93-114, Jan. 1993, https://www.doi.org/10.1088/0031-9155/38/1/007.
C. Ma, D. W. O. Rogers, K. R. Shortt, C. K. Ross, A. E. Nahum, and A. F. Bielajew, “Wall-correction and absorbed-dose conversion factors for Fricke dosimetry: Monte Carlo calculations and measurements”, Medical Physics, vol. 20, no. 2, pp. 283-292, Mar. 1993, https://www.doi.org/10.1118/1.597128.
“Report 16”, Journal of the International Commission on Radiation Units and Measurements, vol. os9, no. 1, p. NP. 1970, https://www.doi.org/10.1093/jicru/os9.1.report16.
J. Meesungnoen, M. Benrahmoune, A. Filali-Mouhim, S. Mankhetkorn, and J.-P. Jay-Gerin, “ Monte Carlo Calculation of the Primary Radical and Molecular Yields of Liquid Water Radiolysis in the Linear Energy Transfer Range 0.3-6.5 keV/μm: Application to 137 Cs Gamma Rays 1”, Radiation Research, vol. 155, no. 2, pp. 269-278, Feb. 2001, https://www.doi.org/10.1667/0033-7587(2001)155[0269:mccotp]2.0.co;2.
T. H. Kirby, W. F. Hanson, and D. A. Johnston, “Uncertainty analysis of absorbed dose calculations from thermoluminescence dosimeters”, Medical Physics, vol. 19, no. 6, pp. 1427-1433, Nov. 1992, https://www.doi.org/10.1118/1.596797.
G. M. Mahmoud and R. S. Hegazy, “Comparison of GUM and Monte Carlo methods for the uncertainty estimation in hardness measurements”, International Journal of Metrology and Quality Engineering, vol. 8, p. 14, May 2017, https://www.doi.org/10.1051/ijmqe/2017014.
I. Farrance and R. Frenkel, “Uncertainty in measurement: a review of monte carlo simulation using microsoft excel for the calculation of uncertainties through functional relationships, including uncertainties in empirically derived constants”, The Clinical Biochemist Reviews, vol. 35, no. 1, pp. 37-61, Feb. 2014, [Online]. Available: http://www.ncbi.nlm.nih.gov/pubmed/24659835.
C.-M. Ma et al., “Effect of statistical uncertainties on Monte Carlo treatment planning”, Physics in Medicine & Biology, vol. 50, no. 5, pp. 891-907, Mar. 2005, https://www.doi.org/10.1088/0031-9155/50/5/013.
B. Thomadsen et al., “93 TG-138 REPORT: UNCERTAINTIES IN PHOTON EMITTING BRACHYTHERAPY SOURCE DOSIMETRY”, Radiotherapy and Oncology, vol. 103, p. S38, May 2012, https://www.doi.org/10.1016/S0167-140(12)72060-1.
J. Wulff, J. T. Heverhagen, K. Zink, and I. Kawrakow, “Investigation of systematic uncertainties in Monte Carlo-calculated beam quality correction factors”, Physics in Medicine & Biology, vol. 55, no. 16, pp. 4481-4493, Jul. 2010, https://www.doi.org/10.1088/0031-9155/55/16/s04.
P. Castro et al., “Study of the uncertainty in the determination of the absorbed dose to water during external beam radiotherapy calibration”, Journal of Applied Clinical Medical Physics, vol. 9, no. 1, pp. 70-86, Dec. 2008, https://www.doi.org/10.1120/jacmp.v9i1.2676.
“Joint Committee for Guides in Metrology (JCGM) 2008 Report 100: Evaluation of Measurement Data-Guide to the Expression of Uncertainty in Measurement” [Online]. Available: https://www.bipm.org/utils/common/documents/jcgm/JCGM_100_2008_E.pdf.
R. J. Shalek and C. E. Smith, “CHEMICAL DOSIMETRY FOR THE MEASUREMENT OF HIGH‐ENERGY PHOTONS AND ELECTRONS”, Annals of the New York Academy of Sciences, vol. 161, no. 1, pp. 44-62, 1969, https://www.doi.org/10.1111/j.1749-6632.1969.tb34040.x.
K. E. Stump, L. A. DeWerd, J. A. Micka, and D. R. Anderson, “Calibration of new high dose rate 192Ir sources”, Medical Physics, vol. 29, no. 7, pp. 1483-1488, 2002, https://www.doi.org/10.1118/1.1487860.
A. Mantuano et al., “Technical Note: Fricke dosimetry for blood irradiators,” Medical Physics, 2020, https://doi.org/10.1002/mp.14487
A. Mantuano, C. Salata, M. G. David, C. L. Mota, G. J. De Amorim, and L. A. G. Magalhães, “Fantoma para Irradiadores de Sangue”, BR 10 2018 073239 0, 2018.
A. Mantuano, C. L. Mota, C. Salata, A. Pickler, L. A. G. Magalhães, and C. E. de Almeida, “A pilot study of a postal dosimetry system using Fricke dosimeter for research irradiators purpose”, Submiss. Process.
C. M. Ma et al., “AAPM protocol for 40-300 kV x-ray beam dosimetry in radiotherapy and radiobiology”, John Wiley and Sons Ltd, 2001. https://www.doi.org/10.1118/1.1374247.
C. Salata et al., “Determination of Absorbed Dose to Water Using Fricke Dosimetry for (6) MV Photons Beams", Medical Physics, vol. 47, no. 6, pp. e255-e880, 2020, https://doi.org/10.1002/mp.14316.
